Inhibition of beta-bungarotoxin action by bee venom phospholipase A2.
نویسندگان
چکیده
(3-Bungarotoxin ((3-BuTX) induces twitching of innervated frog muscle and subsequently blocks transm itter release from motor nerve endings. These actions of P-BuTX are prevented if the nerve-muscle junctions are pretreated with a low concentration of phospholipase A2 from bee venom. When the Ca2+ in the external fluid is replaced by Sr2+, the phospho lipase activity of P-BuTX is negligible and, in these conditions, P-BuTX causes a decrease in the amplitude of endplate potentials but does not go on to block transm itter release completely.
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ورودعنوان ژورنال:
- Proceedings of the Royal Society of London. Series B, Biological sciences
دوره 200 1139 شماره
صفحات -
تاریخ انتشار 1978